浙江省医院药事管理质控中心网-FDA对达比加群酯安全性审查

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FDA对达比加群酯安全性审查

作者：网络来源时间：2012-11-06 点击：344 来源：网络来源

<SPAN lang=EN-US style="WORD-SPACING: 0px; FONT: 12pt/24px Arial; TEXT-TRANSFORM: none; COLOR: black; WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px" xml:lang="EN-US">FDA<SPAN style="WORD-SPACING: 0px; FONT: 12pt/24px 宋体; TEXT-TRANSFORM: none; COLOR: black; WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px">于<SPAN style="DISPLAY: inline! important; FLOAT: none; WORD-SPACING: 0px; FONT: 14px/21px simsun; TEXT-TRANSFORM: none; COLOR: rgb(85,85,85); TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px"> <SPAN lang=EN-US style="WORD-SPACING: 0px; FONT: 12pt/24px Arial; TEXT-TRANSFORM: none; COLOR: black; WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px" xml:lang="EN-US">11<SPAN style="WORD-SPACING: 0px; FONT: 12pt/24px 宋体; TEXT-TRANSFORM: none; COLOR: black; WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px">月<SPAN lang=EN-US style="WORD-SPACING: 0px; FONT: 12pt/24px Arial; TEXT-TRANSFORM: none; COLOR: black; WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px" xml:lang="EN-US">2<SPAN style="WORD-SPACING: 0px; FONT: 12pt/24px 宋体; TEXT-TRANSFORM: none; COLOR: black; WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px">日<SPAN style="WORD-SPACING: 0px; FONT: 12pt/24px 宋体; TEXT-TRANSFORM: none; COLOR: black; WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px">发布公告，已经对与抗凝剂（血液稀化剂）<SPAN lang=EN style="WORD-SPACING: 0px; FONT: 12pt/24px Arial; TEXT-TRANSFORM: none; COLOR: black; WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px" xml:lang="EN"><A style="COLOR: rgb(100,129,76); TEXT-DECORATION: none" href="http://www.drugs.com/pradaxa.html">Pradaxa</A><SPAN style="WORD-SPACING: 0px; FONT: 12pt/24px 宋体; TEXT-TRANSFORM: none; COLOR: black; WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px">（<SPAN lang=EN style="WORD-SPACING: 0px; FONT: 12pt/24px Arial; TEXT-TRANSFORM: none; COLOR: black; WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px" xml:lang="EN"><A style="COLOR: rgb(100,129,76); TEXT-DECORATION: none" href="http://www.drugs.com/cdi/dabigatran.html">dabigatran</A><SPAN style="WORD-SPACING: 0px; FONT: 12pt/24px 宋体; TEXT-TRANSFORM: none; COLOR: black; WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px">，<SPAN style="WORD-SPACING: 0px; FONT: 12pt/24px 宋体; TEXT-TRANSFORM: none; COLOR: black; WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px">达比加群酯）和华法林（商品名<SPAN lang=EN style="WORD-SPACING: 0px; FONT: 12pt/24px Arial; TEXT-TRANSFORM: none; COLOR: black; WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px" xml:lang="EN">Coumadin<SPAN style="WORD-SPACING: 0px; FONT: 12pt/24px 宋体; TEXT-TRANSFORM: none; COLOR: black; WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px">、<SPAN lang=EN style="WORD-SPACING: 0px; FONT: 12pt/24px Arial; TEXT-TRANSFORM: none; COLOR: black; WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px" xml:lang="EN">Jantoven<SPAN style="WORD-SPACING: 0px; FONT: 12pt/24px 宋体; TEXT-TRANSFORM: none; COLOR: black; WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px">。国内注册名：<SPAN style="WORD-SPACING: 0px; FONT: 12pt/24px 宋体; TEXT-TRANSFORM: none; COLOR: black; WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px">可密定<SPAN style="WORD-SPACING: 0px; FONT: 12pt/24px 宋体; TEXT-TRANSFORM: none; COLOR: black; WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px">）使用相关的严重出血<SPAN style="WORD-SPACING: 0px; FONT: 12pt/24px 宋体; TEXT-TRANSFORM: none; COLOR: rgb(51,51,51); WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px">风险新的信息进行了评估。信息取自<SPAN lang=EN-US style="WORD-SPACING: 0px; FONT: 12pt/24px Arial; TEXT-TRANSFORM: none; COLOR: rgb(51,51,51); WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px" xml:lang="EN-US">FDA<SPAN style="WORD-SPACING: 0px; FONT: 12pt/24px 宋体; TEXT-TRANSFORM: none; COLOR: rgb(51,51,51); WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px">的“<SPAN lang=EN style="WORD-SPACING: 0px; FONT: 12pt/24px Arial; TEXT-TRANSFORM: none; COLOR: rgb(51,51,51); WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px" xml:lang="EN">Mini-Sentinel pilot of the Sentinel Initiative<SPAN style="WORD-SPACING: 0px; FONT: 12pt/24px 宋体; TEXT-TRANSFORM: none; COLOR: rgb(51,51,51); WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px">”<SPAN style="WORD-SPACING: 0px; FONT: 12pt/24px 宋体; TEXT-TRANSFORM: none; COLOR: rgb(51,51,51); WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px">保险理赔和管理数据库。评估结果表明，与<SPAN lang=EN style="WORD-SPACING: 0px; FONT: 12pt/24px Arial; TEXT-TRANSFORM: none; COLOR: black; WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px" xml:lang="EN"><A style="COLOR: rgb(100,129,76); TEXT-DECORATION: none" href="http://www.drugs.com/pradaxa.html">Pradaxa</A><SPAN style="WORD-SPACING: 0px; FONT: 12pt/24px 宋体; TEXT-TRANSFORM: none; COLOR: black; WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px">新<SPAN style="WORD-SPACING: 0px; FONT: 12pt/24px 宋体; TEXT-TRANSFORM: none; COLOR: black; WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px">用途相关<SPAN style="WORD-SPACING: 0px; FONT: 12pt/24px 宋体; TEXT-TRANSFORM: none; COLOR: rgb(51,51,51); WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px">的出血率并不高于华法林作新用途时所见，这与<SPAN lang=EN style="WORD-SPACING: 0px; FONT: 12pt/24px Arial; TEXT-TRANSFORM: none; COLOR: black; WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px" xml:lang="EN"><A style="COLOR: rgb(100,129,76); TEXT-DECORATION: none" href="http://www.drugs.com/pradaxa.html">Pradaxa</A><SPAN style="WORD-SPACING: 0px; FONT: 12pt/24px 宋体; TEXT-TRANSFORM: none; COLOR: rgb(51,51,51); WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px">作为获准申请依据的一项大型临床试验中观察到的结果相一致。<SPAN style="WORD-SPACING: 0px; FONT: 14px/21px simsun; TEXT-TRANSFORM: none; COLOR: rgb(85,85,85); WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px">FDA<SPAN style="WORD-SPACING: 0px; FONT: 14px/21px simsun; TEXT-TRANSFORM: none; COLOR: rgb(85,85,85); WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px">还在<SPAN style="WORD-SPACING: 0px; FONT: 12pt/24px 宋体; TEXT-TRANSFORM: none; COLOR: rgb(51,51,51); WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px">继续评估多个来源的数据，对<SPAN lang=EN style="WORD-SPACING: 0px; FONT: 12pt/24px Arial; TEXT-TRANSFORM: none; COLOR: black; WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px" xml:lang="EN"><A style="COLOR: rgb(100,129,76); TEXT-DECORATION: none" href="http://www.drugs.com/pradaxa.html">Pradaxa</A><SPAN style="WORD-SPACING: 0px; FONT: 12pt/24px 宋体; TEXT-TRANSFORM: none; COLOR: rgb(51,51,51); WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px">进行安全性审查。<SPAN lang=EN-US style="WORD-SPACING: 0px; FONT: 12pt/24px Arial; TEXT-TRANSFORM: none; COLOR: rgb(51,51,51); WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px" xml:lang="EN-US">     FDA<SPAN style="WORD-SPACING: 0px; FONT: 12pt/24px 宋体; TEXT-TRANSFORM: none; COLOR: rgb(51,51,51); WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px">尚未对<SPAN lang=EN style="WORD-SPACING: 0px; FONT: 12pt/24px Arial; TEXT-TRANSFORM: none; COLOR: black; WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px" xml:lang="EN"><A style="COLOR: rgb(100,129,76); TEXT-DECORATION: none" href="http://www.drugs.com/pradaxa.html">Pradaxa</A><SPAN style="WORD-SPACING: 0px; FONT: 12pt/24px 宋体; TEXT-TRANSFORM: none; COLOR: black; WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px">标签和说明书提出修改<SPAN style="WORD-SPACING: 0px; FONT: 12pt/24px 宋体; TEXT-TRANSFORM: none; COLOR: rgb(51,51,51); WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px">建议。按照标签说明使用，<SPAN lang=EN style="WORD-SPACING: 0px; FONT: 12pt/24px Arial; TEXT-TRANSFORM: none; COLOR: black; WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px" xml:lang="EN"><A style="COLOR: rgb(100,129,76); TEXT-DECORATION: none" href="http://www.drugs.com/pradaxa.html">Pradaxa</A><SPAN style="WORD-SPACING: 0px; FONT: 12pt/24px 宋体; TEXT-TRANSFORM: none; COLOR: rgb(51,51,51); WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px">有重要的健康益处。处方<SPAN lang=EN style="WORD-SPACING: 0px; FONT: 12pt/24px Arial; TEXT-TRANSFORM: none; COLOR: black; WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px" xml:lang="EN"><A style="COLOR: rgb(100,129,76); TEXT-DECORATION: none" href="http://www.drugs.com/pradaxa.html">Pradaxa</A><SPAN style="WORD-SPACING: 0px; FONT: 12pt/24px 宋体; TEXT-TRANSFORM: none; COLOR: black; WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px">的医务人员<SPAN style="WORD-SPACING: 0px; FONT: 12pt/24px 宋体; TEXT-TRANSFORM: none; COLOR: rgb(51,51,51); WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px">应认真按照标签推荐的剂量，特别是对肾功能不全（肾脏不能发挥正常功能）患者，以减少出血风险。房颤患者未征求医师同意不应该停止服用<SPAN lang=EN style="WORD-SPACING: 0px; FONT: 12pt/24px Arial; TEXT-TRANSFORM: none; COLOR: black; WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px" xml:lang="EN"><A style="COLOR: rgb(100,129,76); TEXT-DECORATION: none" href="http://www.drugs.com/pradaxa.html">Pradaxa</A><SPAN style="WORD-SPACING: 0px; FONT: 12pt/24px 宋体; TEXT-TRANSFORM: none; COLOR: rgb(51,51,51); WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px">。停止使用如<SPAN lang=EN style="WORD-SPACING: 0px; FONT: 12pt/24px Arial; TEXT-TRANSFORM: none; COLOR: black; WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px" xml:lang="EN"><A style="COLOR: rgb(100,129,76); TEXT-DECORATION: none" href="http://www.drugs.com/pradaxa.html">Pradaxa</A><SPAN style="WORD-SPACING: 0px; FONT: 12pt/24px 宋体; TEXT-TRANSFORM: none; COLOR: black; WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px">一类<SPAN style="WORD-SPACING: 0px; FONT: 12pt/24px 宋体; TEXT-TRANSFORM: none; COLOR: rgb(51,51,51); WORD-BREAK: normal; TEXT-INDENT: 32px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(255,255,255); TEXT-ALIGN: left; WORD-WRAP: normal; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px">抗凝药物可能增加中风风险。中风可导致永久性残疾和死亡。

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