| <P style="BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: 0px; PADDING-BOTTOM: 0px; MARGIN: 0cm 0cm 0pt; WORD-SPACING: 0px; FONT: 14px/21px simsun; TEXT-TRANSFORM: none; COLOR: rgb(85,85,85); WORD-BREAK: normal; TEXT-INDENT: 24pt; PADDING-TOP: 0px; WHITE-SPACE: normal; LIST-STYLE-TYPE: none; LETTER-SPACING: normal; BACKGROUND-COLOR: white; TEXT-ALIGN: left; BORDER-RIGHT-WIDTH: 0px; WORD-WRAP: normal; border-image: initial; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px; background-origin: initial; background-clip: initial" align=left><SPAN style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: 宋体; WORD-WRAP: normal">欧洲药品监管机构</SPAN><FONT size=3><SPAN class=Apple-converted-space><FONT color=#555555> </FONT></SPAN><SPAN lang=EN-US style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: Arial; WORD-WRAP: normal" xml:lang="EN-US">11</SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: 宋体; WORD-WRAP: normal">月</SPAN><SPAN lang=EN-US style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: Arial; WORD-WRAP: normal" xml:lang="EN-US">20</SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: 宋体; WORD-WRAP: normal">日</SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: 宋体; WORD-WRAP: normal">批准了百时美施贵宝公司和其伙伴辉瑞制药潜在的重磅炸弹产品，血液稀化剂</SPAN><SPAN lang=EN-US style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: Arial; WORD-WRAP: normal" xml:lang="EN-US">Eliquis</SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: 宋体; WORD-WRAP: normal">（</SPAN><SPAN lang=EN style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: Arial; WORD-WRAP: normal" xml:lang="EN"><A style="COLOR: rgb(100,129,76); TEXT-DECORATION: none" href="http://www.fiercebiotech.com/tags/apixaban"><SPAN style="COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; TEXT-DECORATION: none; WORD-WRAP: normal"><FONT style="WORD-BREAK: normal; LINE-HEIGHT: 24px; WORD-WRAP: normal" face=Arial>apixaban</FONT></SPAN></A></SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: 宋体; WORD-WRAP: normal">，</SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: 宋体; WORD-WRAP: normal">阿哌沙班）。这一批准是在被美国</SPAN><SPAN lang=EN-US style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: Arial; WORD-WRAP: normal" xml:lang="EN-US">FDA</SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: 宋体; WORD-WRAP: normal">两次推迟通过审批后做出的，</SPAN><SPAN lang=EN-US style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: Arial; WORD-WRAP: normal" xml:lang="EN-US">FDA</SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: 宋体; WORD-WRAP: normal">将于</SPAN><SPAN lang=EN-US style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: Arial; WORD-WRAP: normal" xml:lang="EN-US">2013</SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: 宋体; WORD-WRAP: normal">年</SPAN><SPAN lang=EN-US style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: Arial; WORD-WRAP: normal" xml:lang="EN-US">3</SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: 宋体; WORD-WRAP: normal">月</SPAN><SPAN lang=EN-US style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: Arial; WORD-WRAP: normal" xml:lang="EN-US">17</SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: 宋体; WORD-WRAP: normal">日</SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: 宋体; WORD-WRAP: normal">作出决定。</SPAN></FONT><SPAN lang=EN-US style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: Arial; WORD-WRAP: normal" xml:lang="EN-US"><BR><SPAN style="WORD-BREAK: normal; LINE-HEIGHT: 24px; WORD-WRAP: normal"><FONT style="WORD-BREAK: normal; LINE-HEIGHT: 24px; WORD-WRAP: normal" face=Arial><FONT size=3> <WBR> <WBR> <WBR></FONT></FONT></SPAN></SPAN><FONT size=3><SPAN class=Apple-converted-space><FONT color=#555555> </FONT></SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: 宋体; WORD-WRAP: normal">目前很难估量该药对百时美施贵宝公司和辉瑞制药的极端重要性。一些分析师预计，如果获得</SPAN><SPAN lang=EN-US style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: Arial; WORD-WRAP: normal" xml:lang="EN-US">FDA</SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: 宋体; WORD-WRAP: normal">批准，每年它将可取得</SPAN><SPAN lang=EN-US style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: Arial; WORD-WRAP: normal" xml:lang="EN-US">30</SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: 宋体; WORD-WRAP: normal">亿美元，甚至超过</SPAN><SPAN lang=EN-US style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: Arial; WORD-WRAP: normal" xml:lang="EN-US">50</SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: 宋体; WORD-WRAP: normal">亿美元销售额。由于它被推迟批准，使这个治疗领域它的竞争产品</SPAN><SPAN lang=EN style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: Arial; WORD-WRAP: normal" xml:lang="EN"><A style="COLOR: rgb(100,129,76); TEXT-DECORATION: none" href="http://www.fiercebiotech.com/tags/pradaxa"><SPAN style="COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; TEXT-DECORATION: none; WORD-WRAP: normal"><FONT style="WORD-BREAK: normal; LINE-HEIGHT: 24px; WORD-WRAP: normal" face=Arial>Pradaxa</FONT></SPAN></A></SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: 宋体; WORD-WRAP: normal">（</SPAN><SPAN style="WORD-BREAK: normal; LINE-HEIGHT: 21px; WORD-WRAP: normal"><SPAN lang=EN-US style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: Arial; WORD-WRAP: normal" xml:lang="EN-US">dabigatran etexilate</SPAN></SPAN><SPAN style="WORD-BREAK: normal; LINE-HEIGHT: 21px; WORD-WRAP: normal"><SPAN style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: 宋体; WORD-WRAP: normal">，</SPAN><FONT color=#555555>达比加群</FONT></SPAN><SPAN style="WORD-BREAK: normal; LINE-HEIGHT: 21px; WORD-WRAP: normal"><SPAN lang=ZH style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: 宋体; WORD-WRAP: normal" xml:lang="ZH">酯</SPAN></SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: 宋体; WORD-WRAP: normal">）</SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: 宋体; WORD-WRAP: normal">和</SPAN><SPAN lang=EN style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: Arial; WORD-WRAP: normal" xml:lang="EN"><A style="COLOR: rgb(100,129,76); TEXT-DECORATION: none" href="http://www.fiercebiotech.com/tags/xarelto"><SPAN style="COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; TEXT-DECORATION: none; WORD-WRAP: normal"><FONT style="WORD-BREAK: normal; LINE-HEIGHT: 24px; WORD-WRAP: normal" face=Arial>Xarelto</FONT></SPAN></A></SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: 宋体; WORD-WRAP: normal">（</SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: 宋体; WORD-WRAP: normal">拜瑞妥，</SPAN><SPAN lang=EN style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: Arial; WORD-WRAP: normal" xml:lang="EN">rivaroxaban</SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: 宋体; WORD-WRAP: normal">，利伐沙班</SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: 宋体; WORD-WRAP: normal">）从中获益，但分析师们仍然看到它的上升空间，以及主宰这个重要市场的潜力。</SPAN></FONT><SPAN lang=EN-US style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: Arial; WORD-WRAP: normal" xml:lang="EN-US"><BR><FONT style="WORD-BREAK: normal; LINE-HEIGHT: 24px; WORD-WRAP: normal"><FONT size=3><FONT face=Arial><SPAN style="WORD-BREAK: normal; LINE-HEIGHT: 24px; WORD-WRAP: normal"> <WBR> <WBR> <WBR></SPAN><SPAN class=Apple-converted-space> </SPAN>Eliquis</FONT></FONT></FONT></SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: 宋体; WORD-WRAP: normal">在欧盟获准是百时美施贵宝和辉瑞公司合作的结果，它有助于替代华法林解决非瓣膜性房颤患者中风预防一直未能满足的需要。</SPAN></P>
<P style="BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; BORDER-LEFT-WIDTH: 0px; BORDER-BOTTOM-WIDTH: 0px; PADDING-BOTTOM: 0px; MARGIN: 0cm 0cm 0pt; WORD-SPACING: 0px; FONT: 14px/21px simsun; TEXT-TRANSFORM: none; COLOR: rgb(85,85,85); WORD-BREAK: normal; TEXT-INDENT: 24pt; PADDING-TOP: 0px; WHITE-SPACE: normal; LIST-STYLE-TYPE: none; LETTER-SPACING: normal; BACKGROUND-COLOR: white; TEXT-ALIGN: left; BORDER-RIGHT-WIDTH: 0px; WORD-WRAP: normal; border-image: initial; orphans: 2; widows: 2; webkit-text-size-adjust: auto; webkit-text-stroke-width: 0px; background-origin: initial; background-clip: initial" align=left><SPAN style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: 宋体; WORD-WRAP: normal">心房纤维性颤动患者中风风险是常人的</SPAN><SPAN lang=EN-US style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: Arial; WORD-WRAP: normal" xml:lang="EN-US">5</SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: 宋体; WORD-WRAP: normal">倍，减少这种风险改善治疗状况是一个重要的公共健康任务。</SPAN><FONT style="WORD-BREAK: normal; LINE-HEIGHT: 21px; WORD-WRAP: normal" face="Times New Roman">在欧洲和美国分别有大约</FONT><SPAN lang=EN-US style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: Arial; WORD-WRAP: normal" xml:lang="EN-US">600</SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: 宋体; WORD-WRAP: normal">万房颤患者。加上在</SPAN><SPAN lang=EN-US style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: Arial; WORD-WRAP: normal" xml:lang="EN-US">40</SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: 宋体; WORD-WRAP: normal">岁后发生这种疾病有</SPAN><SPAN lang=EN-US style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: Arial; WORD-WRAP: normal" xml:lang="EN-US">25</SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; WORD-BREAK: normal; LINE-HEIGHT: 24px; FONT-FAMILY: 宋体; WORD-WRAP: normal">％几率，其巨大的价值可想而知。</SPAN></P> |
