| <P style="TEXT-ALIGN: left; PADDING-BOTTOM: 0px; WIDOWS: 2; TEXT-TRANSFORM: none; BACKGROUND-COLOR: rgb(255,255,255); LIST-STYLE-TYPE: none; TEXT-INDENT: 32px; MARGIN: 15px 30px 20px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; FONT: 16px/25px Arial, Helvetica, sans-serif, 宋体; WHITE-SPACE: normal; ORPHANS: 2; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; TEXT-DECORATION: none; PADDING-TOP: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px" align=left>日本学者Takagi等通过荟萃分析发现，替米沙坦不但是有效的血管紧张素Ⅱ受体拮抗剂（ARB）类降压药物，同时还可以有效降低患者三酰甘油水平。与其他ARB类药物比较，替米沙坦有局部过氧化物酶增殖物激活受体γ（PPARγ）激动剂的作用，在动物实验中证实具有调节糖脂代谢的作用。作者通过PubMed检索到22篇有关替米沙坦与其他ARB类药物进行头对头（head-to-head）比较的临床试验，共纳入2571例患者进行荟萃分析。替米沙坦与其他ARB类药物降低低密度脂蛋白（均差 0.92 mg/dl，95%<FONT size=3><FONT face=Arial><SPAN class=Apple-converted-space> </SPAN><EM style="PADDING-BOTTOM: 0px; LIST-STYLE-TYPE: none; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; FONT-FAMILY: Arial, Helvetica, sans-serif, 宋体; FONT-SIZE: 12px; TEXT-DECORATION: none; PADDING-TOP: 0px"><SPAN style="PADDING-BOTTOM: 0px; LIST-STYLE-TYPE: none; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; FONT-FAMILY: Arial, Helvetica, sans-serif, 宋体; FONT-SIZE: 16px; TEXT-DECORATION: none; PADDING-TOP: 0px">CI</SPAN></EM><SPAN class=Apple-converted-space> </SPAN>-4.33 -2.49 mg/dl，<EM style="PADDING-BOTTOM: 0px; LIST-STYLE-TYPE: none; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; FONT-FAMILY: Arial, Helvetica, sans-serif, 宋体; FONT-SIZE: 12px; TEXT-DECORATION: none; PADDING-TOP: 0px"><SPAN style="PADDING-BOTTOM: 0px; LIST-STYLE-TYPE: none; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; FONT-FAMILY: Arial, Helvetica, sans-serif, 宋体; FONT-SIZE: 16px; TEXT-DECORATION: none; PADDING-TOP: 0px">P</SPAN></EM><SPAN class=Apple-converted-space> </SPAN>=0.60）和高密度脂蛋白（均差 0.19 mg/dl，95%<SPAN class=Apple-converted-space> </SPAN><EM style="PADDING-BOTTOM: 0px; LIST-STYLE-TYPE: none; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; FONT-FAMILY: Arial, Helvetica, sans-serif, 宋体; FONT-SIZE: 12px; TEXT-DECORATION: none; PADDING-TOP: 0px"><SPAN style="PADDING-BOTTOM: 0px; LIST-STYLE-TYPE: none; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; FONT-FAMILY: Arial, Helvetica, sans-serif, 宋体; FONT-SIZE: 16px; TEXT-DECORATION: none; PADDING-TOP: 0px">CI</SPAN></EM><SPAN class=Apple-converted-space> </SPAN>-0.77-1.15 mg/dl，<EM style="PADDING-BOTTOM: 0px; LIST-STYLE-TYPE: none; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; FONT-FAMILY: Arial, Helvetica, sans-serif, 宋体; FONT-SIZE: 12px; TEXT-DECORATION: none; PADDING-TOP: 0px"><SPAN style="PADDING-BOTTOM: 0px; LIST-STYLE-TYPE: none; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; FONT-FAMILY: Arial, Helvetica, sans-serif, 宋体; FONT-SIZE: 16px; TEXT-DECORATION: none; PADDING-TOP: 0px">P</SPAN></EM><SPAN class=Apple-converted-space> </SPAN>=0.70）水平无明显差异，但三酰甘油水平替米沙坦组较其他ARB类降低了11 mg/dl（均差 11.14 mg/ dl，95%<SPAN class=Apple-converted-space> </SPAN><EM style="PADDING-BOTTOM: 0px; LIST-STYLE-TYPE: none; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; FONT-FAMILY: Arial, Helvetica, sans-serif, 宋体; FONT-SIZE: 12px; TEXT-DECORATION: none; PADDING-TOP: 0px"><SPAN style="PADDING-BOTTOM: 0px; LIST-STYLE-TYPE: none; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; FONT-FAMILY: Arial, Helvetica, sans-serif, 宋体; FONT-SIZE: 16px; TEXT-DECORATION: none; PADDING-TOP: 0px">CI</SPAN></EM><SPAN class=Apple-converted-space> </SPAN>-20.84 -1.44 mg/dl，<EM style="PADDING-BOTTOM: 0px; LIST-STYLE-TYPE: none; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; FONT-FAMILY: Arial, Helvetica, sans-serif, 宋体; FONT-SIZE: 12px; TEXT-DECORATION: none; PADDING-TOP: 0px"><SPAN style="PADDING-BOTTOM: 0px; LIST-STYLE-TYPE: none; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; FONT-FAMILY: Arial, Helvetica, sans-serif, 宋体; FONT-SIZE: 16px; TEXT-DECORATION: none; PADDING-TOP: 0px">P</SPAN></EM><SPAN class=Apple-converted-space> </SPAN></FONT></FONT>=0.02）。因此，作者认为替米沙坦与其他ARB药物相比还有改善三酰甘油代谢的作用。</P>
<P style="TEXT-ALIGN: left; PADDING-BOTTOM: 0px; WIDOWS: 2; TEXT-TRANSFORM: none; BACKGROUND-COLOR: rgb(255,255,255); LIST-STYLE-TYPE: none; TEXT-INDENT: 32px; MARGIN: 15px 30px 20px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; FONT: 16px/25px Arial, Helvetica, sans-serif, 宋体; WHITE-SPACE: normal; ORPHANS: 2; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; TEXT-DECORATION: none; PADDING-TOP: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px" align=center><EM style="PADDING-BOTTOM: 0px; LIST-STYLE-TYPE: none; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; FONT-FAMILY: Arial, Helvetica, sans-serif, 宋体; FONT-SIZE: 12px; TEXT-DECORATION: none; PADDING-TOP: 0px"><SPAN style="PADDING-BOTTOM: 0px; LIST-STYLE-TYPE: none; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; FONT-FAMILY: Arial, Helvetica, sans-serif, 宋体; FONT-SIZE: 16px; TEXT-DECORATION: none; PADDING-TOP: 0px"> Int J Cardiol, 2012, 157:403-452.<BR style="PADDING-BOTTOM: 0px; LIST-STYLE-TYPE: none; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; FONT-FAMILY: Arial, Helvetica, sans-serif, 宋体; FONT-SIZE: 12px; TEXT-DECORATION: none; PADDING-TOP: 0px"> 全文号：IJC(2012-157-3-403)</SPAN></EM></P> |
