| <P style="BACKGROUND: white; LINE-HEIGHT: 12.65pt"><SPAN style="FONT-SIZE: 8pt; COLOR: #3e3e3e; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial"> 美国有研究报告，对健康绝经后女性，</SPAN><SPAN lang=EN-US style="FONT-SIZE: 8pt; COLOR: #3e3e3e; FONT-FAMILY: Arial">HT</SPAN><SPAN style="FONT-SIZE: 8pt; COLOR: #3e3e3e; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">或增加肾结石风险。论文发表于</SPAN><SPAN lang=EN-US style="FONT-SIZE: 8pt; COLOR: #3e3e3e; FONT-FAMILY: Arial">10</SPAN><SPAN style="FONT-SIZE: 8pt; COLOR: #3e3e3e; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">月</SPAN><SPAN lang=EN-US style="FONT-SIZE: 8pt; COLOR: #3e3e3e; FONT-FAMILY: Arial">11</SPAN><SPAN style="FONT-SIZE: 8pt; COLOR: #3e3e3e; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">日刊出的《内科学文献》</SPAN><SPAN lang=EN-US style="FONT-SIZE: 8pt; COLOR: #3e3e3e; FONT-FAMILY: Arial">[Arch Intern Med 2010</SPAN><SPAN style="FONT-SIZE: 8pt; COLOR: #3e3e3e; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">，</SPAN><SPAN lang=EN-US style="FONT-SIZE: 8pt; COLOR: #3e3e3e; FONT-FAMILY: Arial">170</SPAN><SPAN style="FONT-SIZE: 8pt; COLOR: #3e3e3e; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">（</SPAN><SPAN lang=EN-US style="FONT-SIZE: 8pt; COLOR: #3e3e3e; FONT-FAMILY: Arial">18</SPAN><SPAN style="FONT-SIZE: 8pt; COLOR: #3e3e3e; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">）：</SPAN><SPAN lang=EN-US style="FONT-SIZE: 8pt; COLOR: #3e3e3e; FONT-FAMILY: Arial">1678]</SPAN><SPAN style="FONT-SIZE: 8pt; COLOR: #3e3e3e; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">。 </SPAN><SPAN lang=EN-US style="FONT-SIZE: 8pt; COLOR: #3e3e3e; FONT-FAMILY: Arial"><?xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" /><o:p></o:p></SPAN></P>
<P style="BACKGROUND: white; LINE-HEIGHT: 12.65pt"><SPAN style="FONT-SIZE: 8pt; COLOR: #3e3e3e; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial"> 研究者回顾分析美国</SPAN><SPAN lang=EN-US style="FONT-SIZE: 8pt; COLOR: #3e3e3e; FONT-FAMILY: Arial">40</SPAN><SPAN style="FONT-SIZE: 8pt; COLOR: #3e3e3e; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">个临床中心开展的妇女健康倡议（</SPAN><SPAN lang=EN-US style="FONT-SIZE: 8pt; COLOR: #3e3e3e; FONT-FAMILY: Arial">WHI</SPAN><SPAN style="FONT-SIZE: 8pt; COLOR: #3e3e3e; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">）研究中肾结石发生率。</SPAN><SPAN lang=EN-US style="FONT-SIZE: 8pt; COLOR: #3e3e3e; FONT-FAMILY: Arial">WHI</SPAN><SPAN style="FONT-SIZE: 8pt; COLOR: #3e3e3e; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">研究纳入</SPAN><SPAN lang=EN-US style="FONT-SIZE: 8pt; COLOR: #3e3e3e; FONT-FAMILY: Arial">10739</SPAN><SPAN style="FONT-SIZE: 8pt; COLOR: #3e3e3e; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">名已切除子宫的绝经女性，随机予结合型雌激素（</SPAN><SPAN lang=EN-US style="FONT-SIZE: 8pt; COLOR: #3e3e3e; FONT-FAMILY: Arial">CEE</SPAN><SPAN style="FONT-SIZE: 8pt; COLOR: #3e3e3e; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">，</SPAN><SPAN lang=EN-US style="FONT-SIZE: 8pt; COLOR: #3e3e3e; FONT-FAMILY: Arial">0.625 mg/d</SPAN><SPAN style="FONT-SIZE: 8pt; COLOR: #3e3e3e; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">）或安慰剂，纳入</SPAN><SPAN lang=EN-US style="FONT-SIZE: 8pt; COLOR: #3e3e3e; FONT-FAMILY: Arial">16608</SPAN><SPAN style="FONT-SIZE: 8pt; COLOR: #3e3e3e; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">名有子宫的绝经后女性予</SPAN><SPAN lang=EN-US style="FONT-SIZE: 8pt; COLOR: #3e3e3e; FONT-FAMILY: Arial">CEE+</SPAN><SPAN style="FONT-SIZE: 8pt; COLOR: #3e3e3e; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">醋酸甲羟孕酮（</SPAN><SPAN lang=EN-US style="FONT-SIZE: 8pt; COLOR: #3e3e3e; FONT-FAMILY: Arial">2.5 mg/d</SPAN><SPAN style="FONT-SIZE: 8pt; COLOR: #3e3e3e; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">）或安慰剂。</SPAN><SPAN lang=EN-US style="FONT-SIZE: 8pt; COLOR: #3e3e3e; FONT-FAMILY: Arial">CEE</SPAN><SPAN style="FONT-SIZE: 8pt; COLOR: #3e3e3e; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">和雌孕激素试验组分别平均随访</SPAN><SPAN lang=EN-US style="FONT-SIZE: 8pt; COLOR: #3e3e3e; FONT-FAMILY: Arial">7.1</SPAN><SPAN style="FONT-SIZE: 8pt; COLOR: #3e3e3e; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">年和</SPAN><SPAN lang=EN-US style="FONT-SIZE: 8pt; COLOR: #3e3e3e; FONT-FAMILY: Arial">5.6</SPAN><SPAN style="FONT-SIZE: 8pt; COLOR: #3e3e3e; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">年，评估肾结石发生率。结果为，接受</SPAN><SPAN lang=EN-US style="FONT-SIZE: 8pt; COLOR: #3e3e3e; FONT-FAMILY: Arial">HT</SPAN><SPAN style="FONT-SIZE: 8pt; COLOR: #3e3e3e; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">者发生肾结石的风险显著升高（</SPAN><SPAN lang=EN-US style="FONT-SIZE: 8pt; COLOR: #3e3e3e; FONT-FAMILY: Arial">39</SPAN><SPAN style="FONT-SIZE: 8pt; COLOR: #3e3e3e; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">例</SPAN><SPAN lang=EN-US style="FONT-SIZE: 8pt; COLOR: #3e3e3e; FONT-FAMILY: Arial">/1</SPAN><SPAN style="FONT-SIZE: 8pt; COLOR: #3e3e3e; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">万人</SPAN><SPAN lang=EN-US style="FONT-SIZE: 8pt; COLOR: #3e3e3e; FONT-FAMILY: Arial">-</SPAN><SPAN style="FONT-SIZE: 8pt; COLOR: #3e3e3e; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">年对</SPAN><SPAN lang=EN-US style="FONT-SIZE: 8pt; COLOR: #3e3e3e; FONT-FAMILY: Arial">34</SPAN><SPAN style="FONT-SIZE: 8pt; COLOR: #3e3e3e; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">例</SPAN><SPAN lang=EN-US style="FONT-SIZE: 8pt; COLOR: #3e3e3e; FONT-FAMILY: Arial">/1</SPAN><SPAN style="FONT-SIZE: 8pt; COLOR: #3e3e3e; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">万人</SPAN><SPAN lang=EN-US style="FONT-SIZE: 8pt; COLOR: #3e3e3e; FONT-FAMILY: Arial">-</SPAN><SPAN style="FONT-SIZE: 8pt; COLOR: #3e3e3e; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">年，</SPAN><SPAN lang=EN-US style="FONT-SIZE: 8pt; COLOR: #3e3e3e; FONT-FAMILY: Arial">HR=1.21</SPAN><SPAN style="FONT-SIZE: 8pt; COLOR: #3e3e3e; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">），停止研究用药后</SPAN><SPAN lang=EN-US style="FONT-SIZE: 8pt; COLOR: #3e3e3e; FONT-FAMILY: Arial">HR</SPAN><SPAN style="FONT-SIZE: 8pt; COLOR: #3e3e3e; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">升至</SPAN><SPAN lang=EN-US style="FONT-SIZE: 8pt; COLOR: #3e3e3e; FONT-FAMILY: Arial">1.39</SPAN><SPAN style="FONT-SIZE: 8pt; COLOR: #3e3e3e; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">。肾结石风险升高与是否联用孕激素无关，分组前肾结石病史对结果无显著影响。</SPAN><SPAN lang=EN-US style="FONT-SIZE: 8pt; COLOR: #3e3e3e; FONT-FAMILY: Arial"><o:p></o:p></SPAN></P> |
