| <P class=MsoNormal style="BACKGROUND: white; MARGIN: 0cm 0cm 0pt; LINE-HEIGHT: 16.5pt; TEXT-ALIGN: left; mso-pagination: widow-orphan; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto" align=left><FONT size=3><SPAN style="COLOR: #3e3e3e; FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial"> 英国和加拿大学者报告，重组因子</SPAN><SPAN style="COLOR: #3e3e3e; FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt; mso-bidi-font-family: 宋体">Ⅶ</SPAN><SPAN lang=EN-US style="COLOR: #3e3e3e; FONT-FAMILY: Arial; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt">a</SPAN><SPAN style="COLOR: #3e3e3e; FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">不能作为止血剂用于非血友病患者。论文于</SPAN><?xml:namespace prefix = st1 ns = "urn:schemas-microsoft-com:office:smarttags" /><st1:chsdate w:st="on" IsROCDate="False" IsLunarDate="False" Day="15" Month="11" Year="2010"><SPAN lang=EN-US style="COLOR: #3e3e3e; FONT-FAMILY: Arial; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt">2010</SPAN><SPAN style="COLOR: #3e3e3e; FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">年</SPAN><SPAN lang=EN-US style="COLOR: #3e3e3e; FONT-FAMILY: Arial; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt">11</SPAN><SPAN style="COLOR: #3e3e3e; FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">月</SPAN><SPAN lang=EN-US style="COLOR: #3e3e3e; FONT-FAMILY: Arial; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt">15</SPAN><SPAN style="COLOR: #3e3e3e; FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">日</SPAN></st1:chsdate><SPAN style="COLOR: #3e3e3e; FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">在线发表于《加拿大医学会杂志》（</SPAN><SPAN lang=EN-US style="COLOR: #3e3e3e; FONT-FAMILY: Arial; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt">CMAJ</SPAN><SPAN style="COLOR: #3e3e3e; FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">）。</SPAN><SPAN lang=EN-US style="COLOR: #3e3e3e; FONT-FAMILY: Arial; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt"> <?xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" /><o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal style="BACKGROUND: white; MARGIN: 0cm 0cm 0pt; LINE-HEIGHT: 16.5pt; TEXT-ALIGN: left; mso-pagination: widow-orphan; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto" align=left><FONT size=3><SPAN style="COLOR: #3e3e3e; FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial"> 研究者对</SPAN><SPAN lang=EN-US style="COLOR: #3e3e3e; FONT-FAMILY: Arial; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt">2010</SPAN><SPAN style="COLOR: #3e3e3e; FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">年</SPAN><SPAN lang=EN-US style="COLOR: #3e3e3e; FONT-FAMILY: Arial; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt">1</SPAN><SPAN style="COLOR: #3e3e3e; FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">月前发表的</SPAN><SPAN lang=EN-US style="COLOR: #3e3e3e; FONT-FAMILY: Arial; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt">26</SPAN><SPAN style="COLOR: #3e3e3e; FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">项随机对照临床试验进行荟萃分析，其中，</SPAN><SPAN lang=EN-US style="COLOR: #3e3e3e; FONT-FAMILY: Arial; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt">14</SPAN><SPAN style="COLOR: #3e3e3e; FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">项为预防性、</SPAN><SPAN lang=EN-US style="COLOR: #3e3e3e; FONT-FAMILY: Arial; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt">12</SPAN><SPAN style="COLOR: #3e3e3e; FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">项为治疗性应用重组因子</SPAN><SPAN style="COLOR: #3e3e3e; FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt; mso-bidi-font-family: 宋体">Ⅶ</SPAN><SPAN lang=EN-US style="COLOR: #3e3e3e; FONT-FAMILY: Arial; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt">a</SPAN><SPAN style="COLOR: #3e3e3e; FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">。</SPAN><SPAN lang=EN-US style="COLOR: #3e3e3e; FONT-FAMILY: Arial; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt"> <o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal style="BACKGROUND: white; MARGIN: 0cm 0cm 0pt; LINE-HEIGHT: 16.5pt; TEXT-ALIGN: left; mso-pagination: widow-orphan; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto" align=left><FONT size=3><SPAN style="COLOR: #3e3e3e; FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial"> 结果为，在前者中，未发现重组因子</SPAN><SPAN style="COLOR: #3e3e3e; FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt; mso-bidi-font-family: 宋体">Ⅶ</SPAN><SPAN lang=EN-US style="COLOR: #3e3e3e; FONT-FAMILY: Arial; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt">a</SPAN><SPAN style="COLOR: #3e3e3e; FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">与安慰剂组患者的死亡和血栓性事件发生情况存在显著性差异，但重组因子</SPAN><SPAN style="COLOR: #3e3e3e; FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt; mso-bidi-font-family: 宋体">Ⅶ</SPAN><SPAN lang=EN-US style="COLOR: #3e3e3e; FONT-FAMILY: Arial; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt">a</SPAN><SPAN style="COLOR: #3e3e3e; FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">组患者在失血量、红细胞输注量及须输血人数方面略占优势。在后者中，重组因子</SPAN><SPAN style="COLOR: #3e3e3e; FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt; mso-bidi-font-family: 宋体">Ⅶ</SPAN><SPAN lang=EN-US style="COLOR: #3e3e3e; FONT-FAMILY: Arial; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt">a</SPAN><SPAN style="COLOR: #3e3e3e; FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">组死亡率略降低，而血栓性事件发生率略增加，但差异均无显著性；在失血量或红细胞输注方面，两组间无差异。</SPAN></FONT><SPAN lang=EN-US style="COLOR: #3e3e3e; FONT-FAMILY: Arial; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt"><o:p></o:p></SPAN></P> |
