| <DIV><FONT size=2>2012年1月18日，加拿大诺华制药公司与加拿大卫生部联合向医疗专业人员发布关于含阿里克伦产品的安全性信息更新称，对2型糖尿病患者使用阿里克伦的心肾终点试验(ALTITUDE)的中期结果的审查显示，阿里克伦治疗的患者中发生非致死性中风、肾脏并发症(终末期肾病及肾死亡)、高钾血症以及低血压的发生率增高。</FONT></DIV>
<DIV><FONT size=2>阿里克伦(商品名RASILEZ)目前用于治疗轻度至中度原发性高血压病。可单独使用，也可与噻嗪类利尿剂、血管紧张素转换酶抑制剂、血管紧张素Ⅱ1型受体阻断剂或二氢钙通道阻滞剂联用。阿里克伦与氢氯噻嗪的合剂(商品名RASILEZ HCT)则用于宜进行联合治疗的轻中度原发性高血压病患者。</FONT></DIV>
<DIV><FONT size=2>ALTITUDE试验是全球多中心、随机、双盲、安慰剂对照研究，在具有致死性或非致死性心血管和肾脏事件风险的2型糖尿病患者中进行，目的是评估阿里克伦对降低这类患者心血管和肾脏事件发生率的潜在效益。该试验共纳入8606例患者，其中包括329例加拿大患者。在试验中，阿里克伦300mg(或安慰剂)与血管紧张素转换酶(ACE)抑制剂或血管紧张素受体阻滞剂(ARB)的标准治疗联合给药。</FONT></DIV>
<DIV><FONT size=2>ALTITUDE试验的主要终点是以下事件之一的初次发病：心血管性死亡、突然死亡后复活、非致死性心肌梗塞、非致死性中风、因心脏衰竭意外入院、基线血清肌酐浓度成倍增至正常值上限以上(并持续至少一个月)、终末期肾病或肾死亡的发病。</FONT></DIV>
<DIV><FONT size=2>数据监督委员会(DMC)对ALTITUDE试验进行了定期评估，仅18-24个月后便发现不良事件发生率分布的不均衡。此次中期分析的结果如下表所示。</FONT></DIV>
<DIV><FONT size=2></FONT> </DIV>
<DIV><FONT size=2></FONT> </DIV>
<TABLE style="BORDER-RIGHT: medium none; BORDER-TOP: medium none; BORDER-LEFT: medium none; WIDTH: 435.75pt; BORDER-BOTTOM: medium none; BORDER-COLLAPSE: collapse" cellSpacing=0 cellPadding=0 width=581 border=1>
<TBODY>
<TR>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; BORDER-TOP: windowtext 1pt solid; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0cm; BORDER-LEFT: windowtext 1pt solid; WIDTH: 68.4pt; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=91>
<DIV><FONT size=2>变量</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; BORDER-TOP: windowtext 1pt solid; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>阿里克伦组</FONT></DIV>
<DIV><FONT size=2>(N=4283)</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; BORDER-TOP: windowtext 1pt solid; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>安慰剂组</FONT></DIV>
<DIV><FONT size=2>(N=4296)</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; BORDER-TOP: windowtext 1pt solid; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>总计</FONT></DIV>
<DIV><FONT size=2>(N=8579)</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; BORDER-TOP: windowtext 1pt solid; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 36pt; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=48>
<DIV><FONT size=2>HR</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; BORDER-TOP: windowtext 1pt solid; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>95%CI</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; BORDER-TOP: windowtext 1pt solid; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 43.6pt; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=58>
<DIV><FONT size=2>P值</FONT></DIV></TD></TR>
<TR>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0cm; BORDER-LEFT: windowtext 1pt solid; WIDTH: 68.4pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=91>
<DIV><FONT size=2>主要复合终点</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>581(13.6%)</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>542(12.6%)</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>1123(13.1%)</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 36pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=48>
<DIV><FONT size=2>1.09</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>(0.97,1.22)</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 43.6pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=58>
<DIV><FONT size=2>0.1663</FONT></DIV></TD></TR>
<TR>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0cm; BORDER-LEFT: windowtext 1pt solid; WIDTH: 68.4pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=91>
<DIV><FONT size=2>次要复合终点-CV</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>444(10.4%)</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>396(9.2%)</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>840(9.8%)</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 36pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=48>
<DIV><FONT size=2>1.14</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>(0.99,1.30)</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 43.6pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=58>
<DIV><FONT size=2>0.0664</FONT></DIV></TD></TR>
<TR>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0cm; BORDER-LEFT: windowtext 1pt solid; WIDTH: 68.4pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=91>
<DIV><FONT size=2>次要复合终点-肾</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>166(3.9%)</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>180(4.2%)</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>346(4.0%)</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 36pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=48>
<DIV><FONT size=2>0.93</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>(0.76,1.15)</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 43.6pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=58>
<DIV><FONT size=2>0.5178</FONT></DIV></TD></TR>
<TR>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0cm; BORDER-LEFT: windowtext 1pt solid; WIDTH: 68.4pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=91>
<DIV><FONT size=2>事件</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 367.6pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=490 colSpan=6>
<DIV><FONT size=2></FONT> </DIV></TD></TR>
<TR>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0cm; BORDER-LEFT: windowtext 1pt solid; WIDTH: 68.4pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=91>
<DIV><FONT size=2>CV性死亡</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>179(4.2%)</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>162(3.8%)</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>341(4.0%)</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 36pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=48>
<DIV><FONT size=2>1.12</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>(0.90,1.38)</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 43.6pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=58>
<DIV><FONT size=2>0.3110</FONT></DIV></TD></TR>
<TR>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0cm; BORDER-LEFT: windowtext 1pt solid; WIDTH: 68.4pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=91>
<DIV><FONT size=2>突然死亡后复活</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>13(0.3%)</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>8(0.2%)</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>21(0.2%)</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 36pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=48>
<DIV><FONT size=2>1.64</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>(0.68,3.95)</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 43.6pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=58>
<DIV><FONT size=2>0.2737</FONT></DIV></TD></TR>
<TR>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0cm; BORDER-LEFT: windowtext 1pt solid; WIDTH: 68.4pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=91>
<DIV><FONT size=2>非致死性MI</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>90(2.1%)</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>88(2.0%)</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>178(2.1%)</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 36pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=48>
<DIV><FONT size=2>1.03</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>(0.77,1.39)</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 43.6pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=58>
<DIV><FONT size=2>0.8302</FONT></DIV></TD></TR>
<TR>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0cm; BORDER-LEFT: windowtext 1pt solid; WIDTH: 68.4pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=91>
<DIV><FONT size=2>非致死性中风</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>112(2.6%)</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>85(2.0%)</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>197(2.3%)</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 36pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=48>
<DIV><FONT size=2>1.34</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>(1.01,1.77)</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 43.6pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=58>
<DIV><FONT size=2>0.0439</FONT></DIV></TD></TR>
<TR>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0cm; BORDER-LEFT: windowtext 1pt solid; WIDTH: 68.4pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=91>
<DIV><FONT size=2>因心脏衰竭意外入院</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>150(3.5%)</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>155(3.6%)</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>305(3.6%)</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 36pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=48>
<DIV><FONT size=2>0.98</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>(0.78,1.23)</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 43.6pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=58>
<DIV><FONT size=2>0.8716</FONT></DIV></TD></TR>
<TR>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0cm; BORDER-LEFT: windowtext 1pt solid; WIDTH: 68.4pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=91>
<DIV><FONT size=2>ESRD/肾死亡的发病</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>72(1.7%)</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>60(1.4%)</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>132(1.5%)</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 36pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=48>
<DIV><FONT size=2>1.22</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>(0.87,1.72)</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 43.6pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=58>
<DIV><FONT size=2>0.2518</FONT></DIV></TD></TR>
<TR>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0cm; BORDER-LEFT: windowtext 1pt solid; WIDTH: 68.4pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=91>
<DIV><FONT size=2>基线血清肌酐浓度成倍增加</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>141(3.3%)</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>159(3.7%)</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>300(3.5%)</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 36pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=48>
<DIV><FONT size=2>0.90</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>(0.71,1.12)</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 43.6pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=58>
<DIV><FONT size=2>0.3431</FONT></DIV></TD></TR>
<TR>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0cm; BORDER-LEFT: windowtext 1pt solid; WIDTH: 68.4pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=91>
<DIV><FONT size=2>全死因死亡</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>297(6.9%)</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>277(6.4%)</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>574(6.7%)</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 36pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=48>
<DIV><FONT size=2>1.08</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 72pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=96>
<DIV><FONT size=2>(0.92,1.27)</FONT></DIV></TD>
<TD style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; BORDER-LEFT-COLOR: #ffffff; PADDING-BOTTOM: 0cm; WIDTH: 43.6pt; BORDER-TOP-COLOR: #ffffff; PADDING-TOP: 0cm; BORDER-BOTTOM: windowtext 1pt solid; BACKGROUND-COLOR: transparent" width=58>
<DIV><FONT size=2>0.3661</FONT></DIV></TD></TR></TBODY></TABLE>
<DIV><FONT size=2></FONT> </DIV>
<DIV><FONT size=2>基于初步的中期分析，DMC得出结论认为试验组患者不太可能从阿里克伦治疗中获益，而且，这些高危人群中非致死性中风、肾脏并发症(终末期肾病及肾死亡)、高钾血症和低血压的发生率较高。</FONT></DIV>
<DIV><FONT size=2>虽然对ALTITUDE中期结果还需进一步的分析，但是，诺华制药和加拿大卫生部现已建议对正在使用ACE抑制剂或ARB的糖尿病患者禁忌使用阿里克伦。他们提醒医疗专业人员，对于糖尿病患者，阿里克伦或含阿里克伦的产品不宜与ACE抑制剂或ARB联合使用，应尽早对使用含阿里克伦产品的糖尿病患者的治疗进行评估，并建议医疗专业人员，不应对正在使用ACE抑制剂或ARB的糖尿病患者开始含阿里克伦产品的治疗，对已开始治疗的应立即停止治疗，必要时应考虑抗高血压替代治疗。</FONT></DIV><SPAN style="FONT-SIZE: 10.5pt"><FONT size=2>（加拿大卫生部网站）</FONT></SPAN> <BR> |
