| <SPAN style="FONT-SIZE: 10.5pt; COLOR: #333333; FONT-FAMILY: 宋体; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 1.0pt; mso-bidi-font-size: 12.0pt; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN; mso-bidi-language: AR-SA"> 美国食品药品管理局近日宣布，含有一种合成的孕酮（曲罗酮）的口服避孕药，可能比其他类型的孕酮类避孕药更易于引起深静脉血栓。</SPAN><SPAN lang=EN-US style="FONT-SIZE: 10.5pt; COLOR: #333333; FONT-FAMILY: Arial; mso-font-kerning: 1.0pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: 宋体; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN; mso-bidi-language: AR-SA">FDA</SPAN><SPAN style="FONT-SIZE: 10.5pt; COLOR: #333333; FONT-FAMILY: 宋体; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 1.0pt; mso-bidi-font-size: 12.0pt; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN; mso-bidi-language: AR-SA">会对含有曲罗酮的避孕药片，包括拜尔公司的</SPAN><SPAN lang=EN-US style="FONT-SIZE: 10.5pt; COLOR: #333333; FONT-FAMILY: Arial; mso-font-kerning: 1.0pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: 宋体; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN; mso-bidi-language: AR-SA">Yaz</SPAN><SPAN style="FONT-SIZE: 10.5pt; COLOR: #333333; FONT-FAMILY: 宋体; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 1.0pt; mso-bidi-font-size: 12.0pt; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN; mso-bidi-language: AR-SA">，</SPAN><SPAN lang=EN-US style="FONT-SIZE: 10.5pt; COLOR: #333333; FONT-FAMILY: Arial; mso-font-kerning: 1.0pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: 宋体; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN; mso-bidi-language: AR-SA">Yasmin</SPAN><SPAN style="FONT-SIZE: 10.5pt; COLOR: #333333; FONT-FAMILY: 宋体; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 1.0pt; mso-bidi-font-size: 12.0pt; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN; mso-bidi-language: AR-SA">，</SPAN><SPAN lang=EN-US style="FONT-SIZE: 10.5pt; COLOR: #333333; FONT-FAMILY: Arial; mso-font-kerning: 1.0pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: 宋体; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN; mso-bidi-language: AR-SA">Safyral</SPAN><SPAN style="FONT-SIZE: 10.5pt; COLOR: #333333; FONT-FAMILY: 宋体; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 1.0pt; mso-bidi-font-size: 12.0pt; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN; mso-bidi-language: AR-SA">和</SPAN><SPAN lang=EN-US style="FONT-SIZE: 10.5pt; COLOR: #333333; FONT-FAMILY: Arial; mso-font-kerning: 1.0pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: 宋体; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN; mso-bidi-language: AR-SA">Beyaz</SPAN><SPAN style="FONT-SIZE: 10.5pt; COLOR: #333333; FONT-FAMILY: 宋体; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 1.0pt; mso-bidi-font-size: 12.0pt; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN; mso-bidi-language: AR-SA">，贴上警示标签。</SPAN><SPAN lang=EN-US style="FONT-SIZE: 10.5pt; COLOR: #333333; FONT-FAMILY: Arial; mso-font-kerning: 1.0pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: 宋体; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN; mso-bidi-language: AR-SA"><BR><FONT size=3><FONT face=Arial><FONT color=#333333><SPAN style="mso-spacerun: yes"> </SPAN><SPAN style="mso-spacerun: yes"> </SPAN></FONT></FONT></FONT></SPAN><SPAN style="FONT-SIZE: 10.5pt; COLOR: #333333; FONT-FAMILY: 宋体; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 1.0pt; mso-bidi-font-size: 12.0pt; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN; mso-bidi-language: AR-SA">最近该机构回顾的流行病学调查报道说，与含有诸如左炔诺孕酮等其他孕酮的避孕药相比，含有曲罗酮的避孕药发生深静脉血栓的风险会高出前者达三倍之多。然而，其他研究却没有类似发现。</SPAN><SPAN lang=EN-US style="FONT-SIZE: 10.5pt; COLOR: #333333; FONT-FAMILY: Arial; mso-font-kerning: 1.0pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: 宋体; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN; mso-bidi-language: AR-SA"><BR><SPAN style="mso-spacerun: yes"><FONT face=Arial color=#333333 size=3> </FONT></SPAN></SPAN><SPAN style="FONT-SIZE: 10.5pt; COLOR: #333333; FONT-FAMILY: 宋体; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 1.0pt; mso-bidi-font-size: 12.0pt; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN; mso-bidi-language: AR-SA">针对含或不含曲罗酮的避孕药产生深静脉血栓的风险比较，除了没能提供一致的评估以外，这些研究也没能将已知或未知的有可能影响医嘱或血栓形成的重要的患者特征考虑在内。</SPAN><SPAN lang=EN-US style="FONT-SIZE: 10.5pt; COLOR: #333333; FONT-FAMILY: Arial; mso-font-kerning: 1.0pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: 宋体; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN; mso-bidi-language: AR-SA"><BR><SPAN style="mso-spacerun: yes"><FONT face=Arial color=#333333 size=3> </FONT></SPAN></SPAN><SPAN style="FONT-SIZE: 10.5pt; COLOR: #333333; FONT-FAMILY: 宋体; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 1.0pt; mso-bidi-font-size: 12.0pt; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN; mso-bidi-language: AR-SA">针对这些原因，尚不能确定在这些流行病学研究中发现的升高的血栓形成概率可直接归因于含曲罗酮的避孕药。但是，这些药物有可能与血栓形成增高有关。</SPAN><SPAN lang=EN-US style="FONT-SIZE: 10.5pt; COLOR: #333333; FONT-FAMILY: Arial; mso-font-kerning: 1.0pt; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: 宋体; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN; mso-bidi-language: AR-SA"><BR><SPAN style="mso-spacerun: yes"><FONT face=Arial color=#333333 size=3> </FONT></SPAN></SPAN><SPAN style="FONT-SIZE: 10.5pt; COLOR: #333333; FONT-FAMILY: 宋体; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 1.0pt; mso-bidi-font-size: 12.0pt; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN; mso-bidi-language: AR-SA">食品药品管理局指出，所有含有孕酮和雌激素的口服避孕药均会在一定程度上增加形成深静脉血栓的风险，并最终会导致肺栓塞。</SPAN> |
