| <DIV style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px auto; WORD-SPACING: 0px; FONT: 12px/18px Simsun; TEXT-TRANSFORM: none; COLOR: rgb(0,0,0); TEXT-INDENT: 24pt; PADDING-TOP: 0px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(243,244,244); webkit-text-size-adjust: auto; WIDOWS: 2; ORPHANS: 2; webkit-text-stroke-width: 0px"><FONT style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 12px; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 21px; PADDING-TOP: 0px"><FONT style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 14pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; PADDING-TOP: 0px"><FONT style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 12px; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 21px; PADDING-TOP: 0px"><FONT style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 10.5pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; PADDING-TOP: 0px"><SPAN style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 10.5pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 24px; PADDING-TOP: 0px">2011</SPAN><SPAN style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 10.5pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 24px; PADDING-TOP: 0px">年<SPAN style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 10.5pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 24px; PADDING-TOP: 0px">4</SPAN>月，澳大利亚治疗产品管理局（<SPAN style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 10.5pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 24px; PADDING-TOP: 0px">TGA</SPAN>）曾经建议医疗专业人员：在<SPAN style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 10.5pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 24px; PADDING-TOP: 0px">23</SPAN>价肺炎球菌疫苗第<SPAN style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 10.5pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 24px; PADDING-TOP: 0px">2</SPAN>次接种后注射部位反应发生率明显升高的分析结果公布之前，不要进行第<SPAN style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 10.5pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 24px; PADDING-TOP: 0px">2</SPAN>剂及后续的<SPAN style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 10.5pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 24px; PADDING-TOP: 0px">23</SPAN>价肺炎球菌疫苗接种。目前，该项分析已经完成，<SPAN style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 10.5pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 24px; PADDING-TOP: 0px">TGA</SPAN>建议不要给免疫功能正常的人常规再次接种<SPAN style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 10.5pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 24px; PADDING-TOP: 0px">23</SPAN>价肺炎球菌疫苗。对于严重肺炎球菌疾病的高危患者，疫苗再接种时应当按产品说明书使用。</SPAN></FONT></FONT></FONT></FONT></DIV>
<DIV style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px auto; WORD-SPACING: 0px; FONT: 12px/18px Simsun; TEXT-TRANSFORM: none; COLOR: rgb(0,0,0); TEXT-INDENT: 24pt; PADDING-TOP: 0px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(243,244,244); webkit-text-size-adjust: auto; WIDOWS: 2; ORPHANS: 2; webkit-text-stroke-width: 0px"><FONT style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 12px; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 21px; PADDING-TOP: 0px"><FONT style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 14pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; PADDING-TOP: 0px"><FONT style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 12px; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 21px; PADDING-TOP: 0px"><FONT style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 10.5pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; PADDING-TOP: 0px"><SPAN style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 10.5pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 24px; PADDING-TOP: 0px">23</SPAN><SPAN style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 10.5pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 24px; PADDING-TOP: 0px">价肺炎球菌疫苗用于预防由肺炎球菌引起的致命感染。<SPAN style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 10.5pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 24px; PADDING-TOP: 0px">TGA</SPAN>分析提到观察到的不良事件与已知的重复接种<SPAN style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 10.5pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 24px; PADDING-TOP: 0px">23</SPAN>价肺炎球菌疫苗后局部反应发生率高的情况相符。分析认为这些不良事件不是由于疫苗生产或处理环节的问题引起。</SPAN></FONT></FONT></FONT></FONT></DIV>
<DIV style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px auto; WORD-SPACING: 0px; FONT: 12px/18px Simsun; TEXT-TRANSFORM: none; COLOR: rgb(0,0,0); TEXT-INDENT: 24pt; PADDING-TOP: 0px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(243,244,244); webkit-text-size-adjust: auto; WIDOWS: 2; ORPHANS: 2; webkit-text-stroke-width: 0px"><FONT style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 12px; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 21px; PADDING-TOP: 0px"><FONT style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 14pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; PADDING-TOP: 0px"><FONT style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 12px; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 21px; PADDING-TOP: 0px"><FONT style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 10.5pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; PADDING-TOP: 0px"><SPAN style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 10.5pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 24px; PADDING-TOP: 0px">TGA</SPAN><SPAN style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 10.5pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 24px; PADDING-TOP: 0px">对再次接种<SPAN style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 10.5pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 24px; PADDING-TOP: 0px">23</SPAN>价肺炎球菌疫苗提出的最新建议包括：</SPAN></FONT></FONT></FONT></FONT></DIV>
<DIV style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px auto; WORD-SPACING: 0px; FONT: 12px/18px Simsun; TEXT-TRANSFORM: none; COLOR: rgb(0,0,0); TEXT-INDENT: 24pt; PADDING-TOP: 0px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(243,244,244); webkit-text-size-adjust: auto; WIDOWS: 2; ORPHANS: 2; webkit-text-stroke-width: 0px"><FONT style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 12px; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 21px; PADDING-TOP: 0px"><FONT style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 14pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; PADDING-TOP: 0px"><FONT style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 12px; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 21px; PADDING-TOP: 0px"><FONT style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 10.5pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; PADDING-TOP: 0px"><SPAN style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 10.5pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 24px; PADDING-TOP: 0px">1. </SPAN><SPAN style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 10.5pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 24px; PADDING-TOP: 0px">再次接种<SPAN style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 10.5pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 24px; PADDING-TOP: 0px">23</SPAN>价肺炎球菌疫苗的应当按照批准的产品说明书使用；</SPAN></FONT></FONT></FONT></FONT></DIV>
<DIV style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px auto; WORD-SPACING: 0px; FONT: 12px/18px Simsun; TEXT-TRANSFORM: none; COLOR: rgb(0,0,0); TEXT-INDENT: 24pt; PADDING-TOP: 0px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(243,244,244); webkit-text-size-adjust: auto; WIDOWS: 2; ORPHANS: 2; webkit-text-stroke-width: 0px"><FONT style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 12px; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 21px; PADDING-TOP: 0px"><FONT style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 14pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; PADDING-TOP: 0px"><FONT style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 12px; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 21px; PADDING-TOP: 0px"><FONT style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 10.5pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; PADDING-TOP: 0px"><SPAN style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 10.5pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 24px; PADDING-TOP: 0px">2. </SPAN><SPAN style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 10.5pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 24px; PADDING-TOP: 0px">免疫功能正常的人不宜常规再次接种；</SPAN></FONT></FONT></FONT></FONT></DIV>
<DIV style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px auto; WORD-SPACING: 0px; FONT: 12px/18px Simsun; TEXT-TRANSFORM: none; COLOR: rgb(0,0,0); TEXT-INDENT: 24pt; PADDING-TOP: 0px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(243,244,244); webkit-text-size-adjust: auto; WIDOWS: 2; ORPHANS: 2; webkit-text-stroke-width: 0px"><FONT style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 12px; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 21px; PADDING-TOP: 0px"><FONT style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 14pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; PADDING-TOP: 0px"><FONT style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 12px; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 21px; PADDING-TOP: 0px"><FONT style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 10.5pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; PADDING-TOP: 0px"><SPAN style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 10.5pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 24px; PADDING-TOP: 0px">3. </SPAN><SPAN style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 10.5pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 24px; PADDING-TOP: 0px">严重肺炎球菌疾病的高危患者应考虑再次接种，但要与上次接种<SPAN style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 10.5pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 24px; PADDING-TOP: 0px">23</SPAN>价肺炎球菌疫苗时隔至少<SPAN style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 10.5pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 24px; PADDING-TOP: 0px">5</SPAN>年。</SPAN></FONT></FONT></FONT></FONT></DIV>
<DIV style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px auto; WORD-SPACING: 0px; FONT: 12px/18px Simsun; TEXT-TRANSFORM: none; COLOR: rgb(0,0,0); TEXT-INDENT: 24pt; PADDING-TOP: 0px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(243,244,244); webkit-text-size-adjust: auto; WIDOWS: 2; ORPHANS: 2; webkit-text-stroke-width: 0px"><SPAN style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 12pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 24px; PADDING-TOP: 0px"><FONT style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 10.5pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 24px; PADDING-TOP: 0px">上述建议仅针对<SPAN style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 10.5pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 24px; PADDING-TOP: 0px">23</SPAN>价肺炎球菌疫苗，不适用于<SPAN style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 10.5pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 24px; PADDING-TOP: 0px">Prevenar</SPAN>（沛儿，七价肺炎球菌结合疫苗）以及<SPAN style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 10.5pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 24px; PADDING-TOP: 0px">Prevenar 13</SPAN>和<SPAN style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 10.5pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 24px; PADDING-TOP: 0px">Synflorix</SPAN>（链球菌疫苗）结合疫苗。</FONT></SPAN></DIV>
<DIV style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px auto; WORD-SPACING: 0px; FONT: 12px/18px Simsun; TEXT-TRANSFORM: none; COLOR: rgb(0,0,0); TEXT-INDENT: 24pt; PADDING-TOP: 0px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(243,244,244); webkit-text-size-adjust: auto; WIDOWS: 2; ORPHANS: 2; webkit-text-stroke-width: 0px"><SPAN style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 12pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 24px; PADDING-TOP: 0px"><FONT style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 10.5pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 24px; PADDING-TOP: 0px">已知<SPAN style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 10.5pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 24px; PADDING-TOP: 0px">23</SPAN>价肺炎球菌疫苗注射部位不良反应的发生率高，可导致广泛肿胀和疼痛，从而限制患者手臂的活动。还可发生蜂窝织炎样反应和脓肿，但属罕见。有关可能的不良反应的更多信息，可以参见<SPAN style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 10.5pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 24px; PADDING-TOP: 0px">23</SPAN>价肺炎球菌疫苗的产品说明书。</FONT></SPAN></DIV>
<DIV style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px auto; WORD-SPACING: 0px; FONT: 12px/18px Simsun; TEXT-TRANSFORM: none; COLOR: rgb(0,0,0); TEXT-INDENT: 306pt; PADDING-TOP: 0px; WHITE-SPACE: normal; LETTER-SPACING: normal; BACKGROUND-COLOR: rgb(243,244,244); TEXT-ALIGN: right; webkit-text-size-adjust: auto; WIDOWS: 2; ORPHANS: 2; webkit-text-stroke-width: 0px" align=right><SPAN style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 12pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 24px; PADDING-TOP: 0px"><FONT style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 10.5pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 24px; PADDING-TOP: 0px">（<SPAN style="PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 10.5pt; PADDING-BOTTOM: 0px; MARGIN: 0px auto; LINE-HEIGHT: 24px; PADDING-TOP: 0px">TGA</SPAN>网站）</FONT></SPAN></DIV> |
