| <P style="BACKGROUND: white; LINE-HEIGHT: 18pt"><?xml:namespace prefix = st1 ns = "urn:schemas-microsoft-com:office:smarttags" /><st1:chsdate w:st="on" Year="2011" Month="2" Day="25" IsLunarDate="False" IsROCDate="False"><SPAN lang=EN-US style="FONT-SIZE: 10.5pt; COLOR: #323232; FONT-FAMILY: Verdana">2011</SPAN><SPAN style="FONT-SIZE: 10.5pt; COLOR: #323232; mso-ascii-font-family: Verdana; mso-hansi-font-family: Verdana">年</SPAN><SPAN lang=EN-US style="FONT-SIZE: 10.5pt; COLOR: #323232; FONT-FAMILY: Verdana">2</SPAN><SPAN style="FONT-SIZE: 10.5pt; COLOR: #323232; mso-ascii-font-family: Verdana; mso-hansi-font-family: Verdana">月</SPAN><SPAN lang=EN-US style="FONT-SIZE: 10.5pt; COLOR: #323232; FONT-FAMILY: Verdana">25</SPAN><SPAN style="FONT-SIZE: 10.5pt; COLOR: #323232; mso-ascii-font-family: Verdana; mso-hansi-font-family: Verdana">日</SPAN></st1:chsdate><SPAN style="FONT-SIZE: 10.5pt; COLOR: #323232; mso-ascii-font-family: Verdana; mso-hansi-font-family: Verdana">，美国食品与药物管理局（</SPAN><SPAN lang=EN-US style="FONT-SIZE: 10.5pt; COLOR: #323232; FONT-FAMILY: Verdana">FDA</SPAN><SPAN style="FONT-SIZE: 10.5pt; COLOR: #323232; mso-ascii-font-family: Verdana; mso-hansi-font-family: Verdana">）发布公告，批准</SPAN><SPAN lang=EN-US style="FONT-SIZE: 10.5pt; COLOR: #323232; FONT-FAMILY: Verdana">Edarbi</SPAN><SPAN style="FONT-SIZE: 10.5pt; COLOR: #323232; mso-ascii-font-family: Verdana; mso-hansi-font-family: Verdana">片剂（活性成分：</SPAN><SPAN lang=EN-US style="FONT-SIZE: 10.5pt; COLOR: #323232; FONT-FAMILY: Verdana">azilsartan medoxomil</SPAN><SPAN style="FONT-SIZE: 10.5pt; COLOR: #323232; mso-ascii-font-family: Verdana; mso-hansi-font-family: Verdana">）治疗成人高血压。</SPAN><SPAN lang=EN-US style="FONT-SIZE: 10.5pt; COLOR: #323232; FONT-FAMILY: Verdana"><?xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" /><o:p></o:p></SPAN></P>
<P style="BACKGROUND: white; LINE-HEIGHT: 18pt"><SPAN style="FONT-SIZE: 10.5pt; COLOR: #323232; mso-ascii-font-family: Verdana; mso-hansi-font-family: Verdana"> 从临床研究中获得的数据显示，</SPAN><SPAN lang=EN-US style="FONT-SIZE: 10.5pt; COLOR: #323232; FONT-FAMILY: Verdana">Edarbi</SPAN><SPAN style="FONT-SIZE: 10.5pt; COLOR: #323232; mso-ascii-font-family: Verdana; mso-hansi-font-family: Verdana">与代文（缬沙坦）和</SPAN><SPAN lang=EN-US style="FONT-SIZE: 10.5pt; COLOR: #323232; FONT-FAMILY: Verdana">Benicar</SPAN><SPAN style="FONT-SIZE: 10.5pt; COLOR: #323232; mso-ascii-font-family: Verdana; mso-hansi-font-family: Verdana">（奥美沙坦）这两种</SPAN><SPAN lang=EN-US style="FONT-SIZE: 10.5pt; COLOR: #323232; FONT-FAMILY: Verdana">FDA</SPAN><SPAN style="FONT-SIZE: 10.5pt; COLOR: #323232; mso-ascii-font-family: Verdana; mso-hansi-font-family: Verdana">批准的降压药相比，在降低</SPAN><SPAN lang=EN-US style="FONT-SIZE: 10.5pt; COLOR: #323232; FONT-FAMILY: Verdana">24</SPAN><SPAN style="FONT-SIZE: 10.5pt; COLOR: #323232; mso-ascii-font-family: Verdana; mso-hansi-font-family: Verdana">小时血压方面更有效。</SPAN><SPAN lang=EN-US style="FONT-SIZE: 10.5pt; COLOR: #323232; FONT-FAMILY: Verdana"><o:p></o:p></SPAN></P>
<P style="BACKGROUND: white; LINE-HEIGHT: 18pt"><SPAN style="FONT-SIZE: 10.5pt; COLOR: #323232; mso-ascii-font-family: Verdana; mso-hansi-font-family: Verdana"> </SPAN><SPAN lang=EN-US style="FONT-SIZE: 10.5pt; COLOR: #323232; FONT-FAMILY: Verdana">“</SPAN><SPAN style="FONT-SIZE: 10.5pt; COLOR: #323232; mso-ascii-font-family: Verdana; mso-hansi-font-family: Verdana">高血压往往被称为</SPAN><SPAN lang=EN-US style="FONT-SIZE: 10.5pt; COLOR: #323232; FONT-FAMILY: Verdana">‘</SPAN><SPAN style="FONT-SIZE: 10.5pt; COLOR: #323232; mso-ascii-font-family: Verdana; mso-hansi-font-family: Verdana">沉默杀手</SPAN><SPAN lang=EN-US style="FONT-SIZE: 10.5pt; COLOR: #323232; FONT-FAMILY: Verdana">’</SPAN><SPAN style="FONT-SIZE: 10.5pt; COLOR: #323232; mso-ascii-font-family: Verdana; mso-hansi-font-family: Verdana">，因为通常直到对身体造成损害时，高血压方才出现症状</SPAN><SPAN lang=EN-US style="FONT-SIZE: 10.5pt; COLOR: #323232; FONT-FAMILY: Verdana">”</SPAN><SPAN style="FONT-SIZE: 10.5pt; COLOR: #323232; mso-ascii-font-family: Verdana; mso-hansi-font-family: Verdana">，</SPAN><SPAN lang=EN-US style="FONT-SIZE: 10.5pt; COLOR: #323232; FONT-FAMILY: Verdana">FDA</SPAN><SPAN style="FONT-SIZE: 10.5pt; COLOR: #323232; mso-ascii-font-family: Verdana; mso-hansi-font-family: Verdana">药物评估和研究中心心血管和肾脏药物产品部主任</SPAN><SPAN lang=EN-US style="FONT-SIZE: 10.5pt; COLOR: #323232; FONT-FAMILY: Verdana">Norman Stockbridge</SPAN><SPAN style="FONT-SIZE: 10.5pt; COLOR: #323232; mso-ascii-font-family: Verdana; mso-hansi-font-family: Verdana">博士说。</SPAN><SPAN lang=EN-US style="FONT-SIZE: 10.5pt; COLOR: #323232; FONT-FAMILY: Verdana">“</SPAN><SPAN style="FONT-SIZE: 10.5pt; COLOR: #323232; mso-ascii-font-family: Verdana; mso-hansi-font-family: Verdana">许多患者的高血压仍未得到充分控制，所以临床上多种治疗选择很重要。</SPAN><SPAN lang=EN-US style="FONT-SIZE: 10.5pt; COLOR: #323232; FONT-FAMILY: Verdana">”<o:p></o:p></SPAN></P>
<P style="BACKGROUND: white; LINE-HEIGHT: 18pt"><SPAN style="FONT-SIZE: 10.5pt; COLOR: #323232; mso-ascii-font-family: Verdana; mso-hansi-font-family: Verdana"> </SPAN><SPAN lang=EN-US style="FONT-SIZE: 10.5pt; COLOR: #323232; FONT-FAMILY: Verdana">Edarbi</SPAN><SPAN style="FONT-SIZE: 10.5pt; COLOR: #323232; mso-ascii-font-family: Verdana; mso-hansi-font-family: Verdana">将有</SPAN><SPAN lang=EN-US style="FONT-SIZE: 10.5pt; COLOR: #323232; FONT-FAMILY: Verdana">80mg</SPAN><SPAN style="FONT-SIZE: 10.5pt; COLOR: #323232; mso-ascii-font-family: Verdana; mso-hansi-font-family: Verdana">和</SPAN><SPAN lang=EN-US style="FONT-SIZE: 10.5pt; COLOR: #323232; FONT-FAMILY: Verdana">40mg</SPAN><SPAN style="FONT-SIZE: 10.5pt; COLOR: #323232; mso-ascii-font-family: Verdana; mso-hansi-font-family: Verdana">两种剂型，推荐的给药剂量为每日</SPAN><SPAN lang=EN-US style="FONT-SIZE: 10.5pt; COLOR: #323232; FONT-FAMILY: Verdana">1</SPAN><SPAN style="FONT-SIZE: 10.5pt; COLOR: #323232; mso-ascii-font-family: Verdana; mso-hansi-font-family: Verdana">次，每次服用</SPAN><SPAN lang=EN-US style="FONT-SIZE: 10.5pt; COLOR: #323232; FONT-FAMILY: Verdana">80mg</SPAN><SPAN style="FONT-SIZE: 10.5pt; COLOR: #323232; mso-ascii-font-family: Verdana; mso-hansi-font-family: Verdana">。</SPAN><SPAN lang=EN-US style="FONT-SIZE: 10.5pt; COLOR: #323232; FONT-FAMILY: Verdana">40mg</SPAN><SPAN style="FONT-SIZE: 10.5pt; COLOR: #323232; mso-ascii-font-family: Verdana; mso-hansi-font-family: Verdana">的剂型可用于为了降低体内盐分而接受高剂量利尿剂治疗的患者。</SPAN><SPAN lang=EN-US style="FONT-SIZE: 10.5pt; COLOR: #323232; FONT-FAMILY: Verdana"><o:p></o:p></SPAN></P>
<P style="BACKGROUND: white; LINE-HEIGHT: 18pt"><SPAN style="FONT-SIZE: 10.5pt; COLOR: #323232; mso-ascii-font-family: Verdana; mso-hansi-font-family: Verdana"> 近三分之一的美国成年人患有高血压。高血压增加卒中、心衰、心脏病发作、肾衰甚至死亡的危险。</SPAN><SPAN lang=EN-US style="FONT-SIZE: 10.5pt; COLOR: #323232; FONT-FAMILY: Verdana"><o:p></o:p></SPAN></P>
<P style="BACKGROUND: white; LINE-HEIGHT: 18pt"><SPAN style="FONT-SIZE: 10.5pt; COLOR: #323232; mso-ascii-font-family: Verdana; mso-hansi-font-family: Verdana"> </SPAN><SPAN lang=EN-US style="FONT-SIZE: 10.5pt; COLOR: #323232; FONT-FAMILY: Verdana">Edarbi</SPAN><SPAN style="FONT-SIZE: 10.5pt; COLOR: #323232; mso-ascii-font-family: Verdana; mso-hansi-font-family: Verdana">是一种血管紧张素</SPAN><SPAN style="FONT-SIZE: 10.5pt; COLOR: #323232">Ⅱ</SPAN><SPAN style="FONT-SIZE: 10.5pt; COLOR: #323232; mso-ascii-font-family: Verdana; mso-hansi-font-family: Verdana">受体阻滞剂（</SPAN><SPAN lang=EN-US style="FONT-SIZE: 10.5pt; COLOR: #323232; FONT-FAMILY: Verdana">ARB</SPAN><SPAN style="FONT-SIZE: 10.5pt; COLOR: #323232; mso-ascii-font-family: Verdana; mso-hansi-font-family: Verdana">），它通过阻断血管紧张素</SPAN><SPAN style="FONT-SIZE: 10.5pt; COLOR: #323232">Ⅱ</SPAN><SPAN style="FONT-SIZE: 10.5pt; COLOR: #323232; mso-ascii-font-family: Verdana; mso-hansi-font-family: Verdana">的作用来降低血压。血管紧张素</SPAN><SPAN style="FONT-SIZE: 10.5pt; COLOR: #323232">Ⅱ</SPAN><SPAN style="FONT-SIZE: 10.5pt; COLOR: #323232; mso-ascii-font-family: Verdana; mso-hansi-font-family: Verdana">是一种升高血压的激素。</SPAN><SPAN lang=EN-US style="FONT-SIZE: 10.5pt; COLOR: #323232; FONT-FAMILY: Verdana"><o:p></o:p></SPAN></P>
<P style="BACKGROUND: white; LINE-HEIGHT: 18pt"><SPAN style="FONT-SIZE: 10.5pt; COLOR: #323232; mso-ascii-font-family: Verdana; mso-hansi-font-family: Verdana"> 临床试验中，服用</SPAN><SPAN lang=EN-US style="FONT-SIZE: 10.5pt; COLOR: #323232; FONT-FAMILY: Verdana">Edarbi</SPAN><SPAN style="FONT-SIZE: 10.5pt; COLOR: #323232; mso-ascii-font-family: Verdana; mso-hansi-font-family: Verdana">的患者报告的不良反应，与服用非活性药物（安慰剂）的患者所报告的类似。</SPAN><SPAN lang=EN-US style="FONT-SIZE: 10.5pt; COLOR: #323232; FONT-FAMILY: Verdana"><o:p></o:p></SPAN></P>
<P style="BACKGROUND: white; LINE-HEIGHT: 18pt"><SPAN style="FONT-SIZE: 10.5pt; COLOR: #323232; mso-ascii-font-family: Verdana; mso-hansi-font-family: Verdana"> </SPAN><SPAN lang=EN-US style="FONT-SIZE: 10.5pt; COLOR: #323232; FONT-FAMILY: Verdana">Edarbi</SPAN><SPAN style="FONT-SIZE: 10.5pt; COLOR: #323232; mso-ascii-font-family: Verdana; mso-hansi-font-family: Verdana">有一个黑框警告，强调应避免给孕妇使用该药物，因为在孕中期或孕晚期服用该药物可能导致发育中的胎儿受到伤害甚至死亡。如果女性在使用该药物期间怀孕，应尽快停药。</SPAN><SPAN lang=EN-US style="FONT-SIZE: 10.5pt; COLOR: #323232; FONT-FAMILY: Verdana"><o:p></o:p></SPAN></P>
<P style="BACKGROUND: white; LINE-HEIGHT: 18pt"><SPAN style="FONT-SIZE: 10.5pt; COLOR: #323232; mso-ascii-font-family: Verdana; mso-hansi-font-family: Verdana"> 相关链接：</SPAN><STRONG><SPAN lang=EN-US style="FONT-SIZE: 10.5pt; COLOR: #323232; FONT-FAMILY: Verdana; mso-bidi-font-family: 宋体"><A href="http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm244722.htm" target=_blank><FONT face=Verdana color=#666666 size=3>FDA approves Edarbi to treat high blood pressure</FONT></A></SPAN></STRONG><SPAN lang=EN-US style="FONT-SIZE: 10.5pt; COLOR: #323232; FONT-FAMILY: Verdana"><o:p></o:p></SPAN></P>
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