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<P><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial">《药物不良反应》杂志上的一项调查研究结果显示，与阿莫西林相比，临床应用阿莫西林</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Arial">/</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial">克拉维酸钾治疗感染性疾病似乎更为安全。</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Arial"><?xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" /><o:p></o:p></SPAN></P>
<P><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial">为比较阿莫西林和阿莫西林</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Arial">/</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial">克拉维酸钾的不良反应，为临床安全用药提供参考。解放军总医院的研究者收集解放军药品不良反应监测中心数据库</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Arial">2000</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial">年</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Arial">3</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial">月至</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Arial">2010</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial">年</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Arial">3</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial">月有关阿莫西林和阿莫西林</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Arial">/</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial">克拉维酸钾的不良反应报告，并进行回顾性分析。</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Arial"><o:p></o:p></SPAN></P>
<P><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial">结果共收集到</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Arial">576</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial">份阿莫西林和阿莫西林</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Arial">/</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial">克拉维酸钾不良反应报告。其中</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Arial">438</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial">份阿莫西林不良反应报告涉及</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Arial">814</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial">例次不良反应，</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Arial">138</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial">份阿莫西林</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Arial">/</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial">克拉维酸钾不良反应报告涉及</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Arial">233</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial">例次不良反应。</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Arial"><o:p></o:p></SPAN></P>
<P><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial">阿莫西林组出现胃肠、循环和中枢神经系统损害的患者比例低于阿莫西林</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Arial">/</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial">克拉维酸钾组，但是阿莫西林组患者出现皮肤及附件损害的患者比例高于阿莫西林</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Arial">/</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial">克拉维酸钾组。</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Arial"><o:p></o:p></SPAN></P>
<P><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial">两组非严重不良反应病例的构成比较为接近，但是阿莫西林组严重不良反应的构成比明显高于阿莫西林</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Arial">/</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial">克拉维酸钾组（</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Arial">7.5% Vs 2.2%</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial">）。</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Arial"><o:p></o:p></SPAN></P>
<P><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial">此外，阿莫西林组对原患疾病影响明显的患者构成比明显高于阿莫西林</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Arial">/</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial">克拉维酸钾组（</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Arial">9.1% Vs 1.4%</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial">）。两组患者不良反应中位发生时间分别为</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Arial">3d</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial">和</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Arial">1d</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial">。</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Arial"><o:p></o:p></SPAN></P> |
