| <P style="MARGIN: 0cm 0cm 0pt; TEXT-INDENT: 24pt; LINE-HEIGHT: 14.4pt; TEXT-ALIGN: left; mso-pagination: widow-orphan; mso-char-indent-count: 2.0" align=left><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">美国</SPAN><SPAN lang=EN-US style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: Arial" XML:LANG="EN-US">FDA</SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">于</SPAN><SPAN lang=EN-US style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: Arial" XML:LANG="EN-US">14</SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">日批准雅培公司的</SPAN><SPAN lang=EN-US style="FONT-SIZE: 12pt; COLOR: #464646; FONT-FAMILY: Arial; mso-font-kerning: 0pt" XML:LANG="EN-US">CREON®</SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: #464646; FONT-FAMILY: 宋体; mso-ascii-font-family: Arial; mso-hansi-font-family: Helvetica; mso-bidi-font-family: Arial; mso-font-kerning: 0pt">（</SPAN><SPAN lang=EN-US style="FONT-SIZE: 12pt; COLOR: #464646; FONT-FAMILY: Arial; mso-font-kerning: 0pt" XML:LANG="EN-US">pancrelipase</SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: #464646; FONT-FAMILY: 宋体; mso-ascii-font-family: Arial; mso-hansi-font-family: Helvetica; mso-bidi-font-family: Arial; mso-font-kerning: 0pt">，</SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">胰脂肪酶）婴儿特定剂量缓释胶囊制剂，治疗由于的囊肿性纤维化（</SPAN><SPAN lang=EN-US style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: Arial" XML:LANG="EN-US">CF</SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">）所致胰腺外分泌功能不全（</SPAN><SPAN lang=EN-US style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: Arial" XML:LANG="EN-US">EPI</SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">）。</SPAN> <SPAN lang=EN-US style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: Arial" XML:LANG="EN-US">3000</SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">单位脂酶胶囊是</SPAN><SPAN lang=EN-US style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: Arial" XML:LANG="EN-US">FDA</SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">批准的该类药物最低剂量制剂。适合婴儿作剂量滴定。</SPAN></P>
<P style="MARGIN: 0cm 0cm 0pt; TEXT-INDENT: 24pt; LINE-HEIGHT: 14.4pt; TEXT-ALIGN: left; mso-pagination: widow-orphan; mso-char-indent-count: 2.0" align=left><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">大多数</SPAN><SPAN lang=EN-US style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: Arial" XML:LANG="EN-US">CF</SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">婴儿需要喂食小剂量胰酶作替代治疗。迄今父母或护理人员需将普通剂量胶囊打开取出部分使用。新的</SPAN><SPAN lang=EN-US style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: Arial" XML:LANG="EN-US">3000</SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">单位脂酶剂量胶囊给使用带来了方便。</SPAN><SPAN lang=EN-US style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: Arial" XML:LANG="EN-US"><BR><SPAN style="mso-spacerun: yes"><FONT face=Arial> <WBR> <WBR> <WBR></FONT></SPAN></SPAN> <SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">大多数与</SPAN><SPAN lang=EN-US style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: Arial" XML:LANG="EN-US">CF</SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">所致</SPAN><SPAN lang=EN-US style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: Arial" XML:LANG="EN-US">EPI</SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">不能正常消化食物，因为他们体内无法产生足够的胰腺酶，从而导致营养不良。</SPAN><SPAN lang=EN-US style="FONT-SIZE: 12pt; COLOR: #464646; FONT-FAMILY: Arial; mso-font-kerning: 0pt" XML:LANG="EN-US">CREON</SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">胶囊的胰酶可在肠道内直接帮助分解脂肪、蛋白质和碳水化合物，让人体更好地消化食物的营养。精确的胰酶替代治疗剂量对囊性纤维化患儿生活至关重要，婴儿特定剂量制剂可供这类患者成长过程中使用，根据需要调整剂量。</SPAN></P> |
